Browsing by Subject "transforming growth factor beta"

Now showing items 1-3 of 3

    • Article  

      Pirfenidone normalizes the tumor microenvironment to improve chemotherapy 

      Polydorou, C.; Mpekris, F.; Papageorgis, P.; Voutouri, C.; Stylianopoulos, T. (2017)
      Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion ...
    • Article  

      Remodeling components of the tumor microenvironment to enhance cancer therapy 

      Gkretsi, V.; Stylianou, A.; Papageorgis, P.; Polydorou, C.; Stylianopoulos, T. (2015)
      Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides tumor progression and poses barriers to the efficacy of cancer therapies. Most common among tumor types are abnormalities in the ...
    • Article  

      Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review) 

      Papageorgis, P.; Stylianopoulos, T. (2015)
      Deregulation of cell signaling homeostasis is a predominant feature of cancer initiation and progression. Transforming growth factor β (TGFβ) is a pleiotropic cytokine, which regulates numerous biological processes of ...